Table 1.
Quantity | HIV-1 | HSV-1 |
---|---|---|
Radius R | 0.05 μm (52) | 0.1 μm (53) |
Spikes/virus | 8–14 (55,56) | 235–480 gD (54) |
∼700 total (44) | ||
Receptor | KD ≈ 5 nM (57) | |
Binding | ΔH ≈ −100 kBT (57) | |
Coreceptor | KD ≈ 4 nM (58) | |
Binding | ΔH ≈ −300 kBT (59) | |
Receptor diff. | 0.044 μm2/s (60) | |
Const. Dr | ||
Coreceptor diff. | 0.05 μm2/s (60) | |
Const. Dc | ||
Host cell radius | T-cell | Epithelial cell |
4 μm (61) | 5 μm (62) | |
Cell receptor | 300–3000 | 6–9 × 106 |
Density | CD4/μm2 (63) | HS/μm2 (64) |
Cell coreceptor | 60 CCR5/μm2 (63) | |
Density |