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. 2009 Jul 22;97(2):415–434. doi: 10.1016/j.bpj.2009.04.053

Figure 4.

Figure 4

Analysis of the dynamics of the initiator module. (A) Phase plane. Gray dotted line, balance curve for [BAXm]T; gray vertical lines, balance curves for [BH3]T (dash dotted, Stress = 0.1; dashed, Stress = 0.6); black-gray solid line, life-to-death trajectory followed by [BH3]T and [BAXm]T, plotted as time series in B. Dashes change color between black and gray every 50 min after the stress signal is applied. (B) The time series of [BH3]T, [BAXm]T, [BAXm]F, and [BH3]F. Stress = 0.1 for t < 30 and 0.6 for t > 30. The black arrow here and later indicates the time of application of stress. (C) Time lags between stimulation and BAXm activation for different values of stress. Open circles, time lags from model simulations; solid line, time lag predicted by Eq. 3. (D) One-parameter bifurcation diagram. Solid and dashed lines correspond to stable and unstable steady states, respectively. (E) Phase plane for three different values of [BCL2]T. Gray dashed line, [BH3]T balance curve for Stress = 0.6; black dashed, gray dotted, and black solid lines, [BAXm]T balance curves for [BCL2]T = 60, 80, and 100, respectively. (F) Two-parameter bifurcation diagram. Black solid lines, saddle-node bifurcation points; gray dashed line, corresponds to one-parameter bifurcation shown in D. The region of bistability is between the black solid lines.