Table 1.
Model components
| Notation | Explanation |
| aC9 | Active caspase 9, p35/p10 |
| ARF | Alternative reading frame of CDKN2A (cyclin-dependent kinase inhibitor 2A) |
| ARF/MDM2 | Dimer of ARF and MDM2 |
| ASPP | Apoptosis-stimulating protein of p53 |
| BAX | BCL2-associated X protein |
| BAXm | Active BAX, inserted in mitochondrial outer membrane |
| BAXm/BCL2 | Dimer of BAXm and BCL2 |
| BCL2 | Class of antiapoptotic BCL subfamily proteins |
| BH3 | Class of proapoptotic BH3-only subfamily proteins |
| BH3/BCL2 | Dimer of BH3 and BCL2 |
| BH3AC | BH3 activators: BIM and t-BID |
| BH3AC/BCL2 | Dimer of BH3AC and BCL2 |
| BH3DR | BH3 de-repressors: PUMA, NOXA, BMF, etc. |
| BH3DR/BCL2 | Dimer of BH3DR and BCL2 |
| C3 | Active form of caspase 3 |
| C9 | Caspase 9, p35/p12 |
| CC, CO | Closed and open states of mitochondrial channels |
| CycE | Cyclin E |
| CytoC | Cytochrome c in cytoplasm |
| CytoCmito | Cytochrome c in mitochondria |
| E2F1 | Transcription factor |
| MDM2 | Mouse double minute 2 homolog |
| p21 | Cyclin-dependent kinase inhibitor |
| p21/CycE | Dimer of p21 and cyclin E |
| p53 | Transcription factor, tumor suppressor protein |
| p73 | Member of p53 family |
| RB | Retinoblastoma protein |
| RB/E2F1 | Dimer of RB and E2F1 |
| RBP | Phosphorylated RB protein |
| SMAC | Second mitochondria-driven activator of caspase, in cytoplasm |
| SMAC/XIAP | Dimer of SMAC and XIAP |
| SMACmito | SMAC in mitochondria |
| XIAP | X-linked inhibitor of apoptosis protein |