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Model analysis of IKs reactivation at a short S1–S2 interval (100 ms) in control (thin line) and in ISO (thick line). Voltage protocols in inset. The dashed line shows the effect of ISO applied after S1 (“ISO step” in inset). (A) Current (IKs). (B) Zone 2 occupancy. (C) Zone 1 occupancy. (D) Open-state occupancy.
