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. 2009 May 6;96(9):3600–3610. doi: 10.1016/j.bpj.2009.01.028

Figure 5.

Figure 5

Representative examples of the family of currents elicited by the current-voltage protocol shown in the inset. The representative current traces of WT-HergA and the mutations of T618I, S621I, H562W, H562W/T618I, and H562W/S621I elicited by the patch clamp protocol are shown at the top of the WT panel. Because of the slow deactivation in H562W, a −120 mV, 3 s prepulse was given to complete deactivation before the next depolarizing test pulse. The vertical bar in the upper right of each panel represents the amplitude of 500 pA. In T618I, the test pulses were depolarized to as high as +90 mV to cover its entire activation range.