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(A) Dofetilide-sensitive tail current-voltage relationships. Activation curves of WT-Herg, H562W, S621I, and H562W/S621I (HW/SI) (B), as well as WT-Herg, H562W, T618I, and H562W/T618I (HW/TI) (C) are shown. The amplitudes of the tail currents are obtained during reversal to −50 mV (for most constructs) except for H562W, S621I, and H562W/S621I, where the tail currents were obtained during repolarization to −120 mV.
