Table 2.
Mean electrophysiological measurements
| Activation | V1/2 ± SE | S ± SE | n |
|---|---|---|---|
| WT | −16 ± 3 | 6 ± 2 | 14 |
| H562W | −25 ± 5∗ | 10 ± 1 | 6 |
| S621I | −28 ± 3 | 3 ± 5 | 3 |
| T618I | +16 ± 2∗ | 19 ± 3 | 5 |
| H562W/S621I | −35 ± 4∗ | 8 ± 1 | 5 |
| H562W/T618I | −12 ± 4 | 11 ± 1 | 13 |
| Deactivation | τ-f | τ-s | n |
| WT | 47 ± 5 | 649 ± 39 | 5 |
| H562W | 394 ± 44∗ | 730 ± 94 | 8 |
| S621I | 71 ± 17 | 565 ± 162 | 3 |
| T618I | 51 ± 6 | 402 ± 64 | 4 |
| H562W/S621I | 135 ± 11 | 993 ± 268 | 7 |
| H562W/T618I | 81 ± 16 | 484 ± 104 | 4 |
| Reversal potential | SE | n | |
| WT | −77 ± 3 | 4 | |
| H562W | −73 ± 3∗ | 6 | |
| T618I | −75 ± 7 | 3 | |
| H562W/T618I | −77 ± 3 | 3 | |
∗
p < 0.05, t-test, compared to WT.