Figure 4.

Effect of increased damage rate on the steady-state mitochondrial activity at different frequencies of fusion events. Selective and nonselective fusion are compared under (a) high (P_m = 1/50) and (b) low (P_m = 1/200) damage rates. The values of P_t, P_f, and duration of fusion event are identical to those used in Fig. 3. Note that, under increased levels of damage, mitochondrial activity is severely reduced when fusion is nonselective. Dotted lines demonstrate that, under increased damage rate, increased frequency of fusion-fission clustering is needed to reach a certain steady-state mitochondrial activity.