Table 2.
Parameters for the MAPK network model
| Parameter | Role | Value | Reference |
|---|---|---|---|
| ds | Upstream signal inactivation rate | 2 | Estimate |
| ɛ | Erk-mediated upstream attenuation factor | 1 | Estimate |
| ks | Receptor-mediated Raf activation rate | 1 | (14) |
| kR | Erk-mediated Raf activation rate | 1.5 | (14) |
| kM | Raf-mediated Mek activation rate | 2.9 | (14) |
| kE | Mek-mediated Erk activation rate | 5.7 | (14) |
| KR | Michaelis-Menten constant for Erk-Raf interaction | 1.5 | (14,28) |
| KM | Michaelis-Menten constant for Raf-Mek interaction | 0.01 | (14) |
| KE | Michaelis-Menten constant for Mek-Erk interaction | 0.05 | (14) |
| dR | Raf inactivation rate | 1 | Estimated from Schoeberl et al. (14) |
| dM | Mek inactivation rate | 2 | Estimated from Schoeberl et al. (14) |
| dE | Erk inactivation rate | 2 | Estimated from Schoeberl et al. (14) |
References are provided for parameters when available; otherwise parameters are marked as estimates. Representative values used in simulations are provided as well.