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Analysis of oligomer formation in DLS. (A) PSD of “small-aggregate peak” before protofibril nucleation becomes increasingly skewed, with its center position shifting slightly. These changes coincide with growth of uniformly sized oligomers seen in AFM (Fig. 3B). (B) Changes in mean hydrodynamic radius <Rh> obtained from double-exponential fits to DLS autocorrelation functions during initial 3 h of oligomer growth.
