Figure 9.

Reconstruction of the major cold-shock protein CspA. Panel A shows the regularized contact map with the predicted contact map in the background. The regularized diagonal contacts pass through the local maxima on the predicted contact map and extend until the predicted contact probability levels off. The selected regularized contacts correspond to the native fold of CspA. False-positive predictions are not included in the reconstruction. The best structure corresponding to the maximum fraction of predicted contacts at relatively low energy is shown in panel B.