Table 1.
Diagnostic indices of blood tests for significant fibrosis
| Test | Cut-off* | κ† | Se | Spe | +PV | −PV | +LR | −LR | DOR | OA | AUROC‡ |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FibroMeter | 0.419 | 0.560 | 80.0 | 76.0 | 78.5 | 77.6 | 3.33 | 0.26 | 12.65 | 78.1 | 0.853 |
| Fibrotest | 0.435 | 0.493 | 67.7 | 81.9 | 80.1 | 70.2 | 3.74 | 0.39 | 9.48 | 74.5 | 0.811 |
| Hepascore | 0.465 | 0.450 | 66.2 | 79.1 | 77.5 | 68.3 | 3.17 | 0.43 | 7.42 | 72.4 | 0.784 |
| APRI | 0.548 | 0.454 | 62.4 | 83.5 | 80.5 | 67.0 | 3.78 | 0.45 | 8.38 | 72.5 | 0.786 |
| Fib-4 | 1.116 | 0.458 | 73.9 | 71.9 | 74.2 | 71.6 | 2.63 | 0.36 | 7.25 | 73.0 | 0.799 |
*
Diagnostic cut-off determined a posteriori according to maximum Youden index; the maximum overall accuracy cut-off (not shown) was close owing to prevalence (0.52) of diagnostic target.
†
κ index measuring the agreement between a blood test and a liver biopsy for the diagnosis of significant fibrosis.
‡
AUROC is independent of cut-off.
AUROC, area under the receiver operating characteristic; DOR, diagnostic odds ratio; LR, likelihood ratio; OA, overall accuracy; PV, predictive value; Se, sensitivity; Spe, specificity.