Table 2.
AUROC (95% CI) of blood tests (grey cells) and their comparisons (P-value of the Delong test) as a function of the diagnostic target
| Significant fibrosis | Severe fibrosis | Cirrhosis | |
|---|---|---|---|
| FibroMeter | 0.853 (0.830–0.876) | 0.885 (0.863–0.906) | 0.907 (0.885–0.929) |
| Fibrotest | 0.811 (0.785–0.838) | 0.837 (0.809–0.865) | 0.882 (0.855–0.910) |
| Hepascore | 0.784 (0.757–0.812) | 0.834 (0.806–0.862) | 0.896 (0.868–0.924) |
| APRI | 0.786 (0.759–0.814) | 0.822 (0.792–0.852) | 0.841 (0.803–0.880) |
| Fib-4 | 0.799 (0.772–0.825) | 0.843 (0.816–0.871) | 0.869 (0.835–0.903) |
| All blood tests | <10−3 | <10−3 | <10−3 |
| FibroMeter vs. Fibrotest | <10−3 | <10−3 | 0.041 |
| FibroMeter vs. Hepascore | <10−3 | <10−3 | 0.203 |
| FibroMeter vs. APRI | <10−3 | <10−3 | <10−3 |
| FibroMeter vs. Fib-4 | <10−3 | <10−3 | 0.008 |
| Fibrotest vs. Hepascore | 0.004 | 0.307 | 0.592 |
| Fibrotest vs. APRI | 0.059 | 0.324 | 0.131 |
| Fibrotest vs. Fib-4 | 0.232 | 0.863 | 0.605 |
| Hepascore vs. APRI | 0.860 | 0.479 | 0.013 |
| Hepascore vs. Fib-4 | 0.327 | 0.587 | 0.202 |
| APRI vs. Fib-4 | 0.210 | 0.037 | 0.021 |
Significant differences are in bold characters.
APRI, aspartate aminotransferase to platelet ratio index; AUROC, area under the receiver operating characteristic.