Figure. Stroke Model Determines Degree of Surviving Tissue and Pattern of Post-Stroke Neurogenesis.

A. Focal cortical stroke produced by permanent occlusion of a distal branch of the MCA and brief bilateral common carotid occlusion²⁹. Box shows the region seen in panel D. B. Large hemispheric stroke produced by 90 minutes of MCA suture occlusion¹²⁹. C. Large cortical infarct produced by permanent distal MCA and ipsilateral CCA occlusion and transient contralateral CCA occlusion¹³⁰. D. Doublecortin positive immature neurons (orange) migrate from the SVZ along the white matter dorsal to the striatum to the peri-infarct cortex (arrows) at 7 days after stroke. Box shows the region that is enlarged in panel E. E. Doublecortin positive cells migrate just ventral to the infarct (arrow) and extend into peri-infarct cortex. Within peri-infarct cortex, immature neurons extend local processes (arrowhead). A comparison of the large infarcts in panels B and D indicate that the region of migration and neurogenesis in peri-infarct cortex would not be present in these stroke models as this tissue is dead. Panel B is reprinted with permission from Brain, Oxford University Press. Panel C is reprinted with permission from Journal of Cerebral Blood Flow & Metabolism, Nature Publishing Group.