Table 2.

Echocardiographic measurements (14 days post-MI)

Parameters	WT-sham	KO-sham	WT-MI	KO-MI	WT-MI+PD	KO-MI+PD	P value
LVEDD (mm)	4.00±0.07	4.00±0.07	5.45±0.26*	6.03±0.13* †	5.13±0.13 (−6.37)	5.20±0.21 (−15.92)#	*<0.001; †<0.05; #<0.01
LVESD (mm)	2.92±0.08	2.99±0.07	4.56±0.22*	5.21±0.14* †	4.03±0.17 (−12.94)	4.12±0.30 (−26.46)#	*<0.001; †<0.05; #<0.01
LVSWd (mm)	0.46±0.02	0.50±0.02	0.75±0.02*	0.67±0.02* †	0.73±0.02 (−1.58)	0.73±0.03 (+8.48)#	*<0.001; †<0.05; #<0.05
LVSWs (mm)	0.64±0.01	0.65±0.01	0.86±0.01*	0.82±0.05*	0.88±0.02 (+1.51)	0.95±0.01 (+13.37)#	*<0.001; #<0.05
FS (%)	27.19±1.19	28.11±1.20	16.44±0.70*	13.65±1.24* †	21.38±1.76 (+23.11) #	21.19±2.71 (+35.57)#	*<0.001; †<0.05; #<0.05
EF (%)	53.33±1.89	54.52±1.84	34.04±1.28*	28.50±2.35* †	42.89±3.06 (+20.64) #	42.32±4.72 (+32.66)#	*<0.001; †<0.05; #<0.05
Heart rate (bpm)	354±9.30	368±7.99	395±15.16	411±17.40	419±18.75	433±21.89	-

Values are mean±SE; n=5 in each group; LVEDD, LV end-diastolic diameter; LVESD, LV end-systolic diameter; LVDSW, LV septal wall thickness in diastole; LVSSW, LV septal wall thickness in systole; %FS, percent fractional shortening; %EF, percent ejection fraction; bpm, beats per minute

^*comparison between sham and MI within genotype

^†comparison between MI groups

^#comparison between MI+PD and MI within genotype; Figures in parenthesis indicate percent increase or decrease from their respective MI values.