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. 2009 May 18;185(4):613–627. doi: 10.1083/jcb.200903034

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© 2009 Szakmary et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 5. — Yb regulates GSC self-renewal in the testis. All samples were stained for the germline marker Vasa (green) and the cytoskeletal marker 1B1 (red) and are shown under the same magnification. (A and B) The testes of the homozygous Yb⁷² mutant (A) or homozygous for both P[myc-piwi]G38 and P[myc-piwi]G47 insertions (B) are morphologically normal, and these males are fully fertile. (C and D) However, homozygous Yb⁷²;P[myc-piwi]G38 testes lose their germline shortly after eclosion and are almost completely sterile. Examples of a weaker (C) and a more severe (D) Yb⁷²;P[myc-piwi]G38 phenotype are shown. C and D also contain the accessory glands (AG), which are similar to wild-type testes in size, as a comparison for reduced size the degenerating testes. ED, ejaculatory duct.