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. 2009 May 18;185(4):743–754. doi: 10.1083/jcb.200901129

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© 2009 Goldoni et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 1. — Decorin affects Met receptor signaling and turnover. (A) Phospho-RTK arrays. HeLa cells were treated with decorin for 15 min. RTK membranes were incubated with cell lysates. The duplicate dots at each corner represent phospho-Tyr positive controls. (B) The same experiment as in A using nonquiescent cells. (C, top) Representative immunoblot of a short decorin time course showing phosphorylation of the Met receptor at Tyr1234/5, total Met, and β-actin. (bottom) Quantification of immunoblots similar to those shown in the top from three independent experiments performed in triplicate. Values represent the mean ± SEM (**, P < 0.01). (D) Best-fit plot of Met receptor degradation over time. Relative values were obtained by scanning densitometry (chemiluminescence) of blots as in C and represent means ± SEM from three independent experiments performed in triplicate.