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. 2009 Jun 15;185(6):1047–1063. doi: 10.1083/jcb.200811099

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© 2009 Rabl et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 9. — Working model of the formation of cristae and CJs in mitochondria. (A) Schematic representation of membrane curvatures at distinct regions of the CM and of the submitochondrial localization of Fcj1 and Su e and Su g in wild-type mitochondria. Positive membrane curvature is indicated in blue, negative curvature in red, and regions with both or no apparent curvature are colored in purple. An overview of a representative cristae sheet with one CJ is shown in side view (left) or as a cross section after 90° rotation (middle). Enlargements of boxed areas in 3D view show the proposed arrangement of Fcj1, Su e/Su g, and of F₁F_O in the respective regions of the CM and their influence on membrane curvature. (B) Schematic representation of membrane curvature in CM structures observed in the indicated mutant mitochondria. Upon depletion of Fcj1, positive curvatures of the CM are predominating, whereas membrane structures that require negative bending of the membrane are absent. The lack of Su e/Su g leads to an apparent reduction in positive membrane curvatures, which results in an enlargement of CJ diameter, branching of cristae, and a strong reduction in the number of apparent cristae tips. Increased levels of Fcj1 produce a similar phenotype. However, the formation of cristae tips is not affected in this mutant. ICS, intracristal space; M, matrix space.