Table 2.
Allelic and genotype distribution frequencies of R521K and T594T polymorphism in the patients and the control groups.
| Polymorphism | Genotypes | Alleles (%) | |||
|---|---|---|---|---|---|
| AA | AG | GG | A | G | |
| EGFR R521K | |||||
| Cases (n = 148) | 12 | 46 | 90 | 70 (23.6) | 226 (76.3) |
| Controls (n = 303) | 26 | 103 | 174 | 155 (25.6) | 451 (74.4) |
| AA versus GG | AA versus AG | AA versus (AG + GG) | A versus G | ||
| Odds ratio | 1.12 | 0.97 | 1.06 | 1.110 | |
| (95%CI) | [0.54–2.17] | [0.45–2.08] | [0.52–2.17] | [0.80–1.53] | |
| Chi-square (P-value) | .09 (.76) | .01 (.93) | .03 (.86) | .40 (.52) | |
| ESR1 T594T | |||||
| Cases (n = 142) | 5 | 36 | 101 | 46 (16.3) | 236 (83.7) |
| Controls (n = 240) | 17 | 76 | 147 | 110 (22.9) | 370 (77.1) |
| AA versus GG | AA versus AG | (AG + AA) versus GG | A versus G | ||
| Odds ratio | 2.33 | 1.61 | 1.56 | 1.54 | |
| (95%CI) | [0.83–6.53] | [0.55–4.71] | [1–2.44] | [1.05–2.25] | |
| Chi-square (P-value) | 2.75 (.10) | .77 (.38) | 3.812 (.05) | 4.96 (.025) | |