Table 3.
True RRR (%) |
PPV of Claims Algorithm to Identify a VCF (%)* |
Observed RRR (%) |
---|---|---|
10 | 74 | 8 |
61 | 6 | |
|
49 |
5 |
30 | 74 | 24 |
61 | 21 | |
|
49 |
17 |
50 | 74 | 43 |
61 | 38 | |
49 | 33 |
VCF = Vertebral Compression Fracture; RRR = Relative Risk Reduction
This analysis shows how the true relative risk reduction associated with a hypothetical osteoporosis medication is attenuated depending on the amount of outcome misclassification of vertebral compression fractures.
estimates derived from the sensitivity analysis in Table 3