Table 3.

Effect of Misclassifying Vertebral Compression Fractures on the Observed Relative Risk Reduction of Fracture associated with Exposure to a Hypothetical Osteoporosis Medication (from [8])

True RRR (%)	PPV of Claims Algorithm to Identify a VCF (%)*	Observed RRR (%)
10	74	8
	61	6
	49	5
30	74	24
	61	21
	49	17
50	74	43
	61	38
	49	33

VCF = Vertebral Compression Fracture; RRR = Relative Risk Reduction

This analysis shows how the true relative risk reduction associated with a hypothetical osteoporosis medication is attenuated depending on the amount of outcome misclassification of vertebral compression fractures.

^*estimates derived from the sensitivity analysis in Table 3