Potential targets of angiogenesis inhibition. Interactions between the tumor cell, its secreted growth factors, and extracellular matrix are all potential targets for angiogenesis inhibition. Figure adapted from Figg et. al. (Ref. 24 Figg, W. D.; Kruger, E. A.; Price, D. K.; Kim, S.; Dahut, W. D. Inhibition of angiogenesis: treatment options for patients with metastatic prostate cancer. Invest. New Drugs 2002, 20, 183–194.)