Fig. 3.
The effect of tamoxifen on NPo does not depend on tonotopic location. Tamoxifen-induced change of NPo (NPoTx/NPocontrol) for each patch is plotted according to the location from which that patch was taken along the basilar papilla. All patches were held at 50 mV. The confidence interval representing NPo stability in control saline is marked in gray. Data within this region were unaffected by drug exposure (▵). Data above (▪) or below (•) this interval were activated or inhibited by Tx, respectively. Overall, the effect of tamoxifen on BK channel open probability is independent of tonotopic location. Black dashed line represents a linear regression to the data.