Fig. 2.

Effects of the 7-day exercise training program on endogenous glucose production. [3-³H]glucose was used to assess glucose kinetics at baseline and during each stage of hyperinsulinemia. Exercise training led to a decrease in basal endogenous hepatic glucose production (HGP) (P = 0.05) plus a reduction in insulin-stimulated HGP during the 40 mU·m⁻²·min⁻¹ hyperinsulinemic stage of the clamp (P = 0.03). HGP was completely suppressed during the 1,000 mU·m⁻²·min⁻¹ stage prior to and after training. P values indicate pre- vs. poststudy comparisons. White bars represent prestudy HGP; black bars represent poststudy HGP. Data are means ± SE; n = 12.