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Glucose homeostasis and plasma sphingolipid profiles in response to myriocin treatment in lean chow-fed C57BL/6J mice. A and B: glucose and insulin tolerance tests, respectively, of control and myriocin-treated lean mice. Data are means ± SD (n = 8). C: plasma ceramide (total), sphingosine, and S1P in control and myriocin-treated mice. D: %change after myriocin treatment in specific ceramide species in plasma. For C and D, data are means ± SD (n = 6). *P < 0.05; **P < 0.01.
