Table 5.
Fatty acid concentrations in serum, brain, and liver
| Fatty acid | Serum |
Brain |
Liver |
|||
|---|---|---|---|---|---|---|
| Adequate |
Deficient |
Adequate |
Deficient |
Adequate |
Deficient |
|
| nmol/ml serum | nmol/ml serum | nmol/g brain | nmol/g brain | nmol/g liver | nmol/g liver | |
| n-6 PUFA | ||||||
| 18:2 | 2627 ± 593 | 492±26*** (−81%) | 477 ± 28 | 261±19*** (−45%) | 18829 ± 4051 | 5593±867*** (−70%) |
| 18:3 | 26 ± 7 | 6±1*** | ND | ND | 392 ± 108 | 99 ± 19*** |
| 20:3 | 92 ± 19 | 58 ± 6*** | 307 ± 17 | 466 ± 29*** | 1135 ± 179 | 1276 ± 200 |
| 20:4 | 2906 ± 415 | 531 ±45*** (−81%) | 12350 ± 397 | 8927±723*** (−28%) | 19496 ± 2742 | 3157 ± 919*** (84%) |
| 22:4 | 69 ± 12 | ND | 2855 ± 107 | 1827 ± 127*** | 500 ± 202 | 102±21*** |
| 22:5 | 21 ± 6 | ND | 96 ± 29 | ND | 320 ± 59 | 68 ± 9*** |
| Total | 5741 ± 1022 | 1088 ± 67*** (−81%) | 16085 ± 454 | 11480 ± 844*** (−29%) | 40672 ± 7146 | 13295 ± 1950*** (67%) |
| n-3 PUFA | ||||||
| 18:3 | 119 ± 39 | 105 ± 14 | ND | ND | 896 ± 285 | 970 ± 250 |
| 20:5 | 91 ± 24 | 535 ± 53*** (+488%) | ND | 236 ± 30 | 512 ± 67 | 5359 ± 732*** (+947%) |
| 22:5 | 171 ± 45 | 138 ± 40 | 207 ± 75 | 537 ± 125*** | 1140 ± 289 | 1774 ± 380 *** |
| 22:6 | 459 ± 84 | 558 ± 89* (+22%) | 15879 ± 546 | 17692 ± 1246** (+11%) | 6459 ± 922 | 11125 ± 1602** * (+72%) |
| Total | 840 ± 169 | 1335 ± 118*** (+59%) | 16086 ± 549 | 18465 ± 1307*** (+15%) | 9008 ± 1485 | 19229 ± 2641*** (+113%) |
| Others | ||||||
| 16:0 | 3854 ± 1075 | 2849 ± 492* | 21906 ± 1821 | 21953 ± 1262 | 47398 ± 11456 | 57438 ± 10838 |
| 16:1n-7 | 671 ± 273 | 548 ± 128 | 331 ± 291 | 388 ± 211 | 9497 ± 3247 | 12575 ± 3070* |
| 18:0 | 1684 ± 244 | 1209 ± 115*** | 24660 ± 223 | 25413 ± 1500 | 20188 ± 2630 | 20693 ± 4601 |
| 18:1n-9 | 1772 ± 578 | 1727 ± 356 | 14691 ± 1673 | 17054 ± 1542** | 19408 ± 5138 | 32175 ± 5567 *** |
| 18:1n-7 | 1093 ± 315 | 1055 ± 165 | 9783 ± 836 | 10368 ± 413 | 12174 ± 2186 | 16982 ± 2229 *** |
| 20:3n-9 | 7 ± 2 | 55 ± 9*** | 30 ± 6 | 253 ± 19** | 116 ± 27 | 991 ± 144*** |
| Total saturated | 5537 ± 1301 | 4058 ± 601** | 46566 ± 2384 | 47366 ± 1746 | 67586 ± 12561 | 78131 ± 11514 |
| Total mono | 3537 ± 1132 | 3330 ± 609 | 24805 ± 2177 | 27810 ± 1586** (+12%) | 41079 ± 10211 | 61731 ± 10247*** (+50%) |
| Total | 15663 ± 3471 | 9867 ± 1292** (−37%) | 103572 ± 4017 | 105374 ± 3573 | 158460 ± 25238 | 173376 ± 22684 |
| Ratio of n-6/n-3 | 6.9 | 0.8 | 1.0 | 0.6 | 4.5 | 0.7 |
| FA composition (% of Total FA) | ||||||
| Total n-6 PUFA | 37% | 11% | 16% | 11% | 26% | 7.7% |
| Total n-3 PUFA | 5.3% | 14% | 16% | 18% | 5.7% | 11% |
| Total saturated | 35% | 41% | 45% | 45% | 43% | 45% |
| Total monounsaturated | 23% | 34% | 24% | 26% | 26% | 36% |
| 20:3n-9 | 0.04% | 0.6% | 0.03% | 0.2% | 0.07% | 0.6% |
Values are mean ± SD (n=10 for both groups).
*
p<0.05
**
p<0.01
***
p<0.001, differs significantly from mean in adequate group.
ND=not detected.