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. Author manuscript; available in PMC: 2009 Jul 16.
Published in final edited form as: Nat Rev Cancer. 2008 Jun 19;8(7):497–511. doi: 10.1038/nrc2402

FIGURE 2. Anatomy of Gene fusions in Prostate Cancer.

FIGURE 2

A cartoon representation of the gene fusions characterized in prostate cancers so far. The 5’ fusion partners are depicted on the left side and corresponding 3’ partners on the right. Light colors at the ends of the genes depict untranslated exons. The dark colored boxes depict coding exons. The numbers on the boxes identify the base positions of the exons. The arrows represent androgen responsiveness of the fusion genes, arrows pointing up (red) signify androgen mediated upregulation; arrows pointing down (green) represent androgen mediated down regulation of the corresponding gene; the horizontal arrows (blue) represent absence of androgen action on the fusion genes’ expression. TMPRSS2-ETS gene fusions have been grouped as Type I; other gene fusions which are androgen inducible have been grouped as Type II, androgen repressed fusion genes make up Type III, Androgen insensitive fusion genes, Type IV, and lastly, the novel situation in prostate cancer cell lines, with ETS genes rearranged to an androgen sensitive location (without the generation of classical gene fusions) has been classified as Type V.