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Activation of TRPP2 by mammalian homolog of Diaphanous related formin 1 (mDia1). At resting membrane potentials, autoinhibited mDia1 (red) binds and blocks TRPP2 activity. In response to EGF or membrane depolarization, mDia1 switches from the autoinhibited state to the activated state, releasing the block on TRPP2. Predicted pore-forming region in TRPP2 is shown in green. Formin homology domains 1 and 2 (FH1 and FH2) are shown as red cylinders.
