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. 2009 May 8;297(1):H331–H339. doi: 10.1152/ajpheart.00007.2009

Fig. 3.

Fig. 3.

Effects of SPR gene transfection on SPR activity and NO• production in vivo. Lipofectamine complexes containing empty vector or SPR gene were transferred to mice circulation via mouse tail vein injection twice a day for 2 days. Mouse aorta was harvested, as indicated in methods, and examined for SPR activity and NO• production. A: SPR protein expression after SPR gene tail vein injection (original mouse SPR and transfected bovine SPR level are both examined). B: effects of SPR gene transfection on SPR activity of mouse aorta. C: effect of SPR gene transfection on H4B content from aorta. D: effect of SPR gene transfection on NO• production from aorta. E: effect of SPR gene transfection on aortic relaxation in response to acetylcholine (ACh). Data are shown as means ± SE from 4–6 individual experiments. *P < 0.05 compared with Ctrl.