Table 1.
Comparison of [3H]GBP binding sites in different tissues from α2/-δ1 WT (+/+), heterozygous (+/−), and knockout (−/−) mice
| Bmax, fmol/mg | Kd, nM | |
|---|---|---|
| Brain | ||
| WT | 3,359±29 | 25±0.5 |
| +/− | 2,757±390 | 36±8.9 |
| −/− | 570±81 | 25±5 |
| Skeletal muscle | ||
| WT | 3,343±961 | 21±3 |
| +/− | 2,268±370 | 20±4 |
| −/− | 145±18* | 11±4 |
| Heart | ||
| WT | 713±227* | 27±12 |
| +/− | 423±202* | 27±18 |
| −/− | 201±193* | 20±7 |
Values are means ± SD. GBP, gabapentin; Bmax, binding maximum; Kd, dissociation equilibrium constant; WT, wild-type.
*
Value is out of detectable range.