Table 2.
Contractile parameters in WT (+/+) and α2/δ-1 (−/−) hearts from isolated working heart preparations
| Parameters | WT | α2/δ-1 (−/−) |
|---|---|---|
| n | 6 | 7 |
| LVSP, mmHg | 119.7±31.4 | 95.7±8.1 |
| LVDP, mmHG | −17.5±6.8 | −7.3±9.2 |
| LVEDP, mmHg | 2.4±4.5 | 13.1±10.1 |
| +dP/dt, mmHg/s | 4,159±893 | 3,134±618* |
| −dP/dt, mmHg/s | 3,727±515 | 2,934±695* |
| Heart rate, beats/min | 352±16.5 | 348±66.7 |
| TPP, ms/mmHg | 0.47±0.07 | 0.52±0.14 |
| TR1/2, ms/mmHg | 0.70±0.15 | 0.70±0.17 |
Values are means ± SD; n, number of hearts. LVSP, left ventricular systolic pressure; LVDP, left ventricular diastolic pressure; LVEDP, left ventricular end-diastolic pressure; +dP/dt, maximal rate of pressure development; −dP/dt, maximal rate of pressure decline; TPP, time to peak pressure, normalized to peak pressure; TR1/2, time to half relaxation pressure, normalized to half relaxation pressure.
*
P < 0.05.