Fig. 1.
Carbon monoxide (CO) and bigenomic transcriptional activity in human skeletal muscle. Real-time RT-PCR was performed on muscle biopsy samples of healthy subjects before and after 5 days of inhaled CO or air exposure and a maximal oxygen uptake (V̇o2max) test, or before and after 5 days inhaled CO without exercise (Ex). Relative levels of mRNA for nuclear-encoded peroxisome proliferator-activated receptor-γ coactivator (PGC-1α) (A), nuclear respiratory factor (NRF)-1 (B), mitochondrial-encoded transcription factor-A (Tfam; C) and DNA polymerase γ (Polγ) (D) are shown before and after CO with or without a V̇o2max test. Values are means ± SD (*P < 0.05 for between-group comparisons).