Fig. 6.
Charge selectivity of Cx43 and Cx40 junctions is unaffected by PKC activation. The dye-charge selectivity results for TPA-treated Rin43 and Rin40 cells are shown as a plot of permeance rate constants for NBD-M-TMA vs. Alexa 350 (only TPA treated shown) (A) and as the average charge selectivities (BNBD-M-TMA/BAlexa 350, treated and untreated shown) (B). For the experiments plotted in A, the parameters were significantly correlated [Cx43: r = 0.98 (n = 5); Cx40: r = 0.88 (n = 4)]. TPA had no detectable effect on selectivity of either the Rin43 or Rin40 junctions.