Fig. 9.

Variable charge selectivity and its regulation in Cx43- and Cx40-coexpressing cells. Individual charge selectivities (B_NBD-M-TMA/B_{Alexa 350}) of the differently comprised junctions studied herein treated (shaded symbols) or not (solid symbols) with TPA (as described in previous figures) and plotted on a logarithmic scale to emphasize the ∼15-fold range in junctional selectivity of coexpressing cells. Note the decreased range of selectivity values in TPA-treated A7r5 cells and absence of similar decrease in Rin40+Cx43tr cells, indicating the necessity for the CT domain for such regulation.