Fig. 6.

In aortas of type 2 diabetic db/db mice, relative mtDNA content (A) was significantly decreased compared with vessels of control mice. In aortas of db/db mice, expression of PGC-1α and Nrf-1 was downregulated (B). Resveratrol (Res) treatment significantly increased vascular mtDNA content (A) and induced the expression of mitochondrial biogenesis factors (B and C) in aortas of db/db mice, eliminating the difference between the 2 groups. Data are means ± SE. *P < 0.05 vs. no resveratrol; #P < 0.05 vs. control mice. wt, Wild-type.