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Effect of MHC composition on the rate of ATP utilization in the rat skinned myocardium. The rate of ATP utilization was measured in the skinned myocardium from euthyroid (∼60% α-MHC, n = 10; □), hyperthyroid (100% α-MHC, n = 12; •), and hypothyroid (0% β-MHC, n = 10; ○) rats and plotted against relative force (P/Po). Forces recorded at submaximal free Ca2+ (P) were expressed relative to the maximal force measured at pCa 4.5 (Po). Data are means ± SE.
