Fig. 4.

Absolute and integrated loss of subendocardial ATP during the first 20 min of simulated ischemia in vitro. Rate of ATP depletion was markedly reduced in hibernating compared with normal control hearts. This was evident in absolute ATP loss from baseline (5.6 ± 0.9 vs. 13.7 ± 1.7 μmol/g dry weight, P < 0.05; left), as well as integrated ATP loss from baseline (19.0 ± 3.4 vs. 37.1 ± 1.6%, P < 0.05; right). Attenuation in rate of ATP depletion was similar in dysfunctional LAD and normally perfused remote location in pigs with hibernating myocardium.