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. 2009 May 8;297(1):H76–H85. doi: 10.1152/ajpheart.01285.2008

Fig. 2.

Fig. 2.

Time-dependent correlation of cardiac IL-18 and OPN expression in pressure /volume overload murine models. This experiment demonstrates that there is a temporal association among expression of IL-18, OPN, and fibrosis in 2 ventricular overload murine models. A: time-dependent gene expression of IL-18 in 1-day, 1-wk, and 1-mo pressure-overloaded cardiac tissue. B: time-dependent IL-18 gene expression in 1-mo volume-overloaded cardiac tissue. C: time-dependent OPN gene expression in 1-day, 1-wk, and 1-mo pressure-overloaded cardiac tissue. D: OPN gene expression in 1-mo volume-overloaded cardiac tissue. E: time-dependent OPN protein expression of IL-18 in 1-day, 1-wk, and 1-mo pressure-overloaded cardiac tissue. F: OPN protein expression in 1-mo volume-overloaded cardiac tissue G: images of picrosirius red (PSR) staining of fibrotic collagen in 1-mo pressure-/volume-overloaded cardiac tissue. H: fibrotic volume quantification of 1-mo pressure-/volume-overloaded cardiac tissue. *P < 0.05 compared with sham controls.