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. 2009 Apr 23;297(1):G107–G115. doi: 10.1152/ajpgi.00057.2009

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Fig. 4. — Effect of K_v7 blockers in segments of murine distal colon. A: effect of the K_v7 blocker XE991 (10 μM) in a segment of distal colon exhibiting only low-amplitude, high-frequency contraction (LAHF) activity. Bottom traces show an amplified section of the contractility in the absence (left) and presence (right) of XE991. B: concentration-effect relationship for the change in integral contractile activity in response to XE991 (**P < 0.01, ***P < 0.005 compared with control). C: effect of 10 μM linopirdine on contractile activity in a segment of distal colon only exhibiting LAHFs and high-amplitude, low-frequency contractions (HALFs). D: a representative trace of the lack of effect of chromanol 293B (30 μM) in the distal colon. Note the stimulatory effect of XE991 (10 μM) applied after chromanol 293B.