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. 2009 Apr 23;297(1):G107–G115. doi: 10.1152/ajpgi.00057.2009

Fig. 5.

Fig. 5.

Effect of XE991 in distal colon segments in the presence of neurotoxins. A: tetrodotoxin (1 μM) abolishes HALF activity and increases baseline LAHF activity. Addition of XE991 (10 μM) causes an additional increase in LAHF activity. B: in a segment exhibiting LALF activity only, tetrodotoxin increases LAHF activity, and addition of XE991 causes a further increase in contractility. C: a concentration of ω-conotoxin MVIIC (1 μM) that is sufficient to block all prejunctional neuronal calcium channels has a similar effect as tetrodotoxin on LAHF and HALF activity. Addition of XE991 caused an increase in LAHF activity in these conditions. D: a lower concentration of ω-conotoxin MVIIC (100 nM) inhibited HALF activity, without modifying LAHF contractions. Under these conditions, addition of XE991 appeared to restore HALF contractions and increase their frequency compared with those observed under control conditions.