Table 1.

Pharmacological features of ET receptor antagonists

Compound	Selectivity	Half-Life	IC50, nM
			ET-A	ET-B
A-147627*	ET-A receptor	6.2 h	0.06	85
A-192621†	ET-B receptor	5.0 h	8,200	6.4
A-182086‡	ET-A receptor	8.1 h	0.08	0.29

ET-A and ET-B, endothelin receptors.

^*Verhaar et al. (30) and Wu-Wong et al. (34).

^†Vassileva et al. (29) and Von Geldern et al. (31).

^‡Wessale et al. (32) and Wu-Wong et al. (34).