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. 2009 Apr 30;297(1):G168–G178. doi: 10.1152/ajpgi.90589.2008

Fig. 3.

Fig. 3.

Clonogenic stem cell survival in FGFR-3−/− mice. A: number of surviving crypts per cross section in proximal jejunum and ileum determined by microcolony assay 3.5 days after 14-Gy γ-irradiation of 19-day-old FGFR-3−/−, FGFR-3+/−, and FGFR-3+/+ mice. Values are means ± SD (n = 6 mice per group). *P < 0.05. †P < 0.01. B: fractional crypt survival determined by normalization to number of crypts in unirradiated FGFR-3−/−, FGFR-3+/−, and FGFR-3+/+ mice. Values are means ± SD (n = 6 mice per group). *P < 0.05. C: ability of stem cells to recover from radiation-induced damage (recovery factor) 84 h after irradiation in 21-day-old mice. Recovery factor was assessed as ratio of crypt stem cell survival in mice that received two 7-Gy γ-irradiation dose fractions separated by a 5-h recovery period to survival in mice that received a single dose of 14 Gy γ-irradiation.

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