Table 1.

Activity comparison of disorazole A₁, epothilone B, and vinblastine against established animal and human cancer cell lines (data taken from refs ¹² and ¹⁴). IC₅₀ values refer to antiproliferative activities

		IC50 (nM)
Cell Line	Origin	Disorazole A1 (1)	Epothilone B	Vinblastine
A549	Human lung carcinoma	0.0023 ± 0.0005	0.26 ± 0.14	5.9 ± 0.5
PC-3	Human prostate adenocarcinoma	0.0071 ± 0.0012	2.0 ± 0.3	0.82 ± 0.06
SK-OV-3	Human ovary adenocarcinoma	0.0049 ± 0.0001	0.64 ± 0.07	1.4 ± 0.1
A-498	Human kidney carcinoma	0.016 ± 0.004	4.3 ± 3.6	46 ± 12
U-937	Human histiocytic lymphoma	0.002 ± 0.001	0.09 ± 0.01	0.43 ± 0.13
K-562	Human myelogenous leukemia	0.006 ± 0.001	0.69 ± 0.03	8.7 ± 1.8
KB-3.1	Human cervix carcinoma	0.0025 ± 0.0003	1.6 ± 0.6	8.6 ± 0.3
KB-V1	Human cervix carcinoma (multi-drug resistant)	0.042 ± 0.008	0.57 ± 0.03	114 ± 31
L929	Mouse fibroblasts	0.0038 ± 0.0002	1.3 ± 0.6	28 ± 7