Fig. 4.

HDAC2 is not detectable in cystic fibrosis (CF) primary nasal tissue by Western blot analysis. HDAC1 levels are not significantly different between CF and non-CF primary tissue. A: Western blot showing HDAC1, HDAC2, and nucleolin expression in human nasal scrape tissue obtained from 3 non-CF and 3 CF subjects. B: densitometry analysis of HDAC1 protein expression normalized to nucleolin content. n = 3. P = 0.5 for the comparison non-CF with CF samples. Significance was determined by t-test. Densitometry analysis for HDAC2 was not possible due to the undetectable levels of HDAC2 in the CF samples.