Table 3.
Reported substrates of β-TrCP reported substrates
| Reported substrates | Function | Degron in humans | Refs |
|---|---|---|---|
| IκBα | Inhibitor of NFκB | DSGLDS | 71–78 |
| IκBβ | Inhibitor of NFκB | DSGLGS | 72 |
| IκBε | Inhibitor of NFκB | DGSIES | 72 |
| p100 | NFκB signalling | DSAYGS | 174–175 |
| p105 | NFκB signalling | DSGVETS | 176–177 |
| WEE1 | CDK1 inhibitory kinase | DSAFQE/EEGFGS | 64 |
| CDC25A | Phosphatase, CDK1 activator | STDSG | 58, 110 |
| CDC25B | Phosphatase, CDK1 activator | DDGFVD/DSGFCLDS | 110 |
| β-catenin | Wnt signalling | DSGIHS | 76, 99–104 |
| PDCD4 | Protein synthesis | DSGRGDS | 84 |
| Claspin | DNA replication and damage stress Transcriptional repressor | DSGQGS | 62, 63 |
| REST | Transcriptional repressor | DEGIHS/STDSG | 93, 106 |
| ATF4 | Transcription factor | DSGICMS | 178 |
| PRL-R | Growth hormone signalling | DSGRGS | 179 |
| CD4 (HIV VPU)* | Viral replication | ND | 180 |
| IFNR | Cytokine signalling | DSGNYS | 181 |
| DLG | Cell contact and polarity | DSGLPS | 182 |
| EMl1‡ | CDH1 inhibitor | DSGYSS | 60 |
| Snail | Animal patterning | DSGKGS | 75 |
| PER1 | Circadian clock transcription | TSGCSS | 183 |
| PER2 | Circadian clock transcription factor | SSGYGS | 184–185 |
| PC2§ | Calcium signalling | ND | 186 |
| MCL1 | Pro-apoptotic protein | DGSLPS | 187 |
| Pro-caspase 3 | Pro-apoptotic protein | ND | 188 |
| p63 | Epithelial differentiation and apoptosis | ND | 189 |
| GHR | Growth hormone signalling | ND | 190 |
| Bora | PLK1 activator | DSGYNT | 191 |
| STAT1 | Transcription factor | ND | 192 |
CD4 has no DSG motif; VPU (viral protein U) targets CD4 to β-TrCP.
Upregulated in β-Trcp−/−mouse embryonic fibroblasts.
PC2 has no DSG motif; tafazzin targets PC2 to β-TrCP. ATF4, activating transcription factor 4; β-TrCP, β-transducin repeat-containing protein; CDC25A, cell division cycle 25A; CDH1, also known as fizzy/cell division cycle 20 related 1 (FZR1); CDK1, cyclin-dependent kinase 1; DLG, discs large tumour suppressor; EMl1, also known as F-box protein 5; GHR, growth hormone receptor; IκB, inhibitor of NFκB; IFNR, interferon receptor; MCL1, myeloid cell leukaemia 1; ND, not determined; NFκB, nuclear factor κB; p100, NFκB2 protein precursor; p105, NFκB1 protein precursor; PC2, protein polycystin 2; PDCD4, programmed cell death 4; PER1, period homologue 1; PLK1, polo-like kinase 1; PRL-R, protein tyrosine phosphatase 4A3; REST, repressor element 1 (RE1)-silencing transcription factor; STAT1, signal transducer and activator of transcription 1.