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. Author manuscript; available in PMC: 2010 Jan 16.
Published in final edited form as: ACS Chem Biol. 2009 Jan 16;4(1):29–40. doi: 10.1021/cb8002804

Table 1.

IC50 of RJF compounds in in-vitro enzyme and cell culture assays of WT and quadruple mutant P. falciparum TS-DHFR

IC50 in WT DHFR
in vitro assay		 in quadruple
mutant DHFR
in vitro assay		 in WT parasite
cell culture		 in quadruple
mutant cell
culture
RJF 00719 21 ± 2 μM 40 ± 2 μM 20 ± 2 μM 19.9 ± 0.5 μM
RJF 01302 29.9 ± 0.5 μM 39.1 ± 0.5 μM 22 ± 3 μM 20 ± 2 μM
RJF 00670 17 ± 2 μM 20 ± 2 μM > 50 μM > 50 μM