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. Author manuscript; available in PMC: 2009 Jul 16.
Published in final edited form as: Biophys Chem. 2007 Mar 24;128(2-3):125–139. doi: 10.1016/j.bpc.2007.03.010

Figure 4. Competition for VEGFR1.

Figure 4

VEGF binding reaches steady state and then PlGF (or unlabeled VEGF) is added. The progression to a new steady state depends on the dimerization method. A, Decrease in VEGF binding and increase in PlGF binding 5 minutes after PlGF addition as a percentage of the change after 60 minutes for LID or DPD as the prevailing dimerization method. B, The difference in the speed of response of LID and DPD (measured as the ratio of the LID and DPD lines in part A) depends on the kinetics of PlGF and VEGF binding. Results shown for VEGF binding decrease after addition of 10 nM PlGF.