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NGF Confers Transforming Activity on the trk Proto-Oncogene Product
| Transforming Activity (Foci per 1.5 × 105 Cells)a |
||||
|---|---|---|---|---|
| trk Gene | Plasmid | Amount of DNA | −NGF | +NGF |
| trk Proto-oncogene | pDM69 | 1 μg | 0 | TMTCb |
| 100 ng | 0 | TMTC | ||
| 10 ng | 0 | 292 | ||
| 1 ng | 0 | 23 | ||
| trk oncogenec | pDM16 | 100 ng | TMTC | TMTC |
| 1 ng | 120 | 113 | ||
Foci were scored 12 days after addition of the DNA.
TMTC, too many to count.
trk oncogene isolated from a human colon carcinoma biopsy (Martin-Zanca et al., 1986).
