Table 2.
Analysis of Metanephric Development
| Developmental age | E11.5 | E13.5 | P0 |
|---|---|---|---|
| Wild type | n = 10 | n = 10 | n = 60 |
| Ureter, branches | 100% | 100% | 100% |
| α8 Mutant | n = 8 | n = 28 | n = 114 |
| No ureter | 0% | 29% | 75% |
| Ureter, not in mesenchyme | 100% | 25% | 0% |
| Ureter, in mesenchyme | 0% | 29% | 9% |
| Ureter, branches | 0% | 18% | 17% |
Wild-type or mutant embryos (E11.5 or E13.5) were sectioned, stained with hematoxilin and eosin, and analyzed for progression of metanephric development. P0 animals were analyzed by dissection and visual inspection.
n, number of ureters analyzed.