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. Author manuscript; available in PMC: 2009 Jul 16.
Published in final edited form as: J Biol Chem. 2006 May 11;281(28):19688–19699. doi: 10.1074/jbc.M601110200

FIGURE 10. Schematic model of β8-integrin regulation of Rho family G-proteins in MC differentiation.

FIGURE 10

The figure on the left represents the normal state, wherein MC differentiation is regulated by αvβ8-dependent docking of RhoGDI-1 with the β8 cytoplasmic tail, which stimulates release of Rac1 from GDI for Rac-GEF interaction. The figure on the right represents the pathologic state, modeled by either decreased β8 or GDI expression, resulting in up-regulated RhoA-dependent α-SMA assembly, which defines pathologic, myofibroblast differentiation.